Selected publications

YearPublications
2025Building a Synthetic Cell Together
Giaveri S, Abil Z, Kohyama S, Fu M, Levrier A, Adamala K, Chinantuya W, Dekker C, Deng N, Fredens J, Hagino K, Jahnke K, Li X, Lindner AB, Liu C, Majumder S, Noireaux V, Schwille P, and Westensee IN*.
Nature Communications 2025:16:7488
Accelerated evolution of whole gene clusters by an engineered lytic phage system in E. coli
Ong S, Ghode P, Narenderan A, Willenborg F, Eden TV, Lao S, Marsh CO, Yew WS, and Fredens J*.
bioRxiv
2023Continuous synthesis of E. coli genome sections and Mb-scale human DNA assembly
Zürcher JF†, Kleefeldt AA†, Funke LFH†, Birnbaum J†, Fredens J†, Grazioli S, Liu KC, Spinck M, Petris G, Murat P, Rehm FBH, Sale JE, and Chin JW*.
Nature 2023:619:555-562
2021Creating custom synthetic genomes in Escherichia coli with REXER and GENESIS
Robertson WE†, Funke LFH†, Torre Ddl†, Fredens J†, Wang K*, and Chin JW*.
Nature Protocols 2021:16:2345-2380
Sense Codon Reassignment Enables Viral Resistance and Encoded Polymer Synthesis
Robertson WE†, Funke LFH†, Torre Ddl†, Fredens J†, Elliott TS, Spinck M, Christova Y, Cervettini D, Böge FL, Liu KC, Buse S, Maslen S, Salmond GPC, and Chin JW*.
Science 2021:372:1057-1062
2019Total synthesis of Escherichia coli with a recoded genome
Fredens J†, Wang K†, Torre Ddl†, Funke LFH†, Robertson WE†, Christova Y, Chia T, Schmied WH, Dunkelmann DL, Beránek V, Uttamapinant C, Llamazares AG, Elliott TS, and Chin JW*.
Nature 2019:569:514-518
2016Defining synonymous codon compression schemes by genome recoding
Wang K*, Fredens J†, Brunner SF†, Kim SH, Chia T, and Chin JW*.
Nature 2016:539:59-64
2014Identification of Novel Protein Functions and Signaling Mechanisms by Genetics and Quantitative Phosphoproteomics in C. elegans
Fredens J†, Engholm-Keller K†, Møller-Jensen J, Larsen MR, and Færgeman NJ*.
Methods in Molecular Biology 2014:1188:107-24
2012Quantitative proteomics by amino acid labeling identifies novel NHR-49 regulated proteins in C. elegans
Fredens J and Færgeman NJ*.
Worm 2012:1:66-71.
2011Quantitative proteomics by amino acid labeling in C. elegans
Fredens J, Engholm-Keller K, Giessing A, Pultz D, Larsen MR, Højrup P, Møller-Jensen J, and Færgeman NJ*.
Nature Methods 2011:8:845-847
† Authors contributed equally
* Corresponding authors