Research

Genome engineering, directed evolution, and large-scale analysis are some of the driving forces behind modern synthetic biology. We combine these wonderful approaches to develop novel biological functions with a variety of applications.

DNA for gene therapy

The promises of gene therapy for future medicine are overwhelming. We are exploring various new strategies for DNA delivery to human cells in culture. This relies on new biochemical assays, engineering, and large-scale analysis.

DNA for gene therapy

The promises of gene therapy for future medicine are overwhelming. We are exploring various new strategies for DNA delivery to human cells in culture. This relies on new biochemical assays, engineering, and large-scale analysis.

Therapeutic phage

Reprogramming bacteriophage to infect new hosts has many interesting academic and technological applications. This research involves comprehensive genome engineering and of multiple different bacteriophage as well as directed evolution through modified phage displays.

Productive cyanobacteria

There is an increasing interest in using this phototrophic microbe for bioproduction, but several issues have to be overcome. We address these obstacles with genome engineering guided by combinations of screening and rational design. The work includes genome manipulation by CRISPR and recombineering.

Productive cyanobacteria

There is an increasing interest in using this phototrophic microbe for bioproduction, but several issues have to be overcome. We address these obstacles with genome engineering guided by combinations of screening and rational design. The work includes genome manipulation by CRISPR and recombineering.