Research
Accelerated evolution of large Gene Clusters Of Interest (GCOI)
By engineering and repurposing a bacteriophage, we have developed Lytic Selection and Evolution (LySE), a platform that allows evolution of large GCOI for bioproduction or biological function without the usual pitfalls. Multiple labs are currently applying the platform for diverse bioengineering purposes.
Retargeting phages to new hosts
Bacteriophages are small, yet complex micromachines that infect one bacterial strain with very high efficiency and specificity. Thus, phages have been studied intensely to understand molecular structure-function relationships, and more recently, they have emerged as potential treatments against Multidrug-Resistant (MDR) bacteria.
Through a combination of engineering and targeted evolution, we work to reprogramme and adapt phages to infect new hosts, for the sake of fundamental understanding and improved treatment.
Carbon-negative bioproduction for a sustainable future
Bioproduction promises green manufacturing of various compounds while reducing the reliance on petrochemicals.
We are developing techniques for precise genome engineering and targeted evolution to improve bioproduction in several strains of cyanobacteria.
Living biosensors for biomarkers and environmental detection
Living biosensors offer specific and affordable, real-time monitoring of target molecules in patients as well as in the environment. For bioproduction, biosensors can guide directed evolution to improve yield and efficiency.
We have recently developed a novel class of biosensors. More information will follow soon.
